Lymphocytes and Granulocytes
Lymphocytes are small white blood cells that play a large role in immune response by protecting the body from disease. Lymphocytes also support the growth of endothelial progenitor cells, which can stimulate angiogenesis, release BMP-2 and BMP-6 and up-regulate the production of BMP-2.8
Granulocytes are a type of white blood cell filled with granules that digest microorganisms. Granulocytes release growth factors that support the development of new blood vessels (angiogenesis) necessary to support tissue regeneration and bone formation.9
Why Concentrated BMA?
Concentrated BMA delivers a highly concentrated sample of stem cells, progenitor cells and growth factors directly to the application site, harnessing the body’s biologic potential.
How Does Concentrated BMA Compare to Allografts and Xenografts?
An allograft is a transplant of an organ or tissue from one individual to another of the same species with a different genotype. For example, a transplant from one person to another person who is not an identical twin is an allograft. Allografts account for many human transplants, including those from cadavers, related living donors and unrelated living donors. Also known as an allogeneic graft or a homograft, a xenograft is tissue taken from a donor of one species and grafted into a recipient of another species—called also heterograft. They are stripped of their cell content due to the risk of an immune reaction upon implantation and are typically used as a biological scaffold.
The advantages of concentrated BMA over allografts and xenografts may include:
- Less risk of immune response39,41
- Higher heterogeneity of stem cells to support tissue regeneration57
- Inexpensive alternative treatment40
Potential risks include:
- Pain at aspiration site
- Excessive bleeding
- Transient neuropathy
Why the Harvest® Bone Marrow Aspirate Concentrate (BMAC®) System?
Used for over a decade, the Harvest BMAC system offers the highest stem cell concentration and yield as compared to five other systems, as shown by the data here.