Scientific References

  1. Data on file.
  2. Kevy SV and MS Jacobson, “Platelet Concentrate Preparation: A Comparison of the Harvest SmartPReP® 2 with the Biomet GPS® III.” Immune Disease Institute 2008.
  3. Jung Y, et al., “Hematopoietic Stem Cells Regulate Mesenchymal Stromal Cell Induction into Osteoblasts Thereby Participating in the Formation of the Stem Cell Niche.” Stem Cells 2008; 26(8): 2042–2051.
  4. Matsumoto T, et al., “Therapeutic Potential of Vasculogenesis and Osteogenesis Promoted by Peripheral Blood CD34-Positive Cells for Functional Bone Healing.” Am J Pathol 2006; 169(4): 1440–1457.
  5. Matsumoto T, et al., “Fracture Induced Mobilization and Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells for Bone Healing.” J Cell Physiol 2008; 215(1): 234–242.
  6. Mifune Y, et al., “Local delivery of Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cells Using Bioscaffold for Modality of Unhealing Bone Fracture.” Stem Cells 2008; 26(6): 1395–1405.
  7. Tondreau T, et al., “Mesenchymal Stem Cells Derived from CD133-Positive Cells in Mobilized Peripheral Blood and Cord Blood: Proliferation, Oct4 Expression, and Plasticity.” Stem Cells 2005; 23(8): 1105–1112.
  8. Hur J, et al., “Identification of a Novel Role of T-Cells in Postnatal Vasculogenesis: Characterization of Endothelial Progenitor Cell Colonies.” Circulation 2007; 116(15): 1671–1682.
  9. Kusumanto YH, et al., “Platelets and Granulocytes, in Particular the Neutrophils, Form Important Compartments for Circulating Vascular Endothelial Growth Factor.” Angiogenesis 2003; 6(4): 283–287.
  10. Muschler G, et al., “Comparison of Bone Marrow Aspiration and Bone Core Biopsy as Methods for Harvest and Assay of Human Connective Tissue Progenitor.” Scientific paper 41; 2006, presented at 58th Association of Bone and Joint Surgeons Meeting.
  11. Nurden A, et al., “Platelets and Wound Healing.” Front Biosci 2008; 13: 3532–3548.
  12. Kevy SV and MS Jacobson, “Comparison of Methods for Point of Care Preparation of Autologous Platelet Gel.” J Extra Corpor Technol 2004; 36(1): 28–35.
  13. Giusti I, et al., “Identification of an Optimal Concentration of Platelet Gel for Promoting Angiogenesis in Human Endothelial Cells.” Transfusion 2009; 49(4): 771–778.
  14. Marx RE, “Platelet-Rich Plasma: Evidence to Support its Use.” J Oral Maxillofac Surg 2004; 62(4): 489–496.
  15. Kevy S, et al., “Defining the Composition and Healing Effect of Platelet-Rich Plasma for Regenerative Medicine.” 2010 TERMIS Americas. Orlando, Florida. 5 to 8 December 2010. Poster session.
  16. Center for Blood Research Laboratories, “Sterility of Platelet Concentrates Collected with the SmartPrep System and Disposables.” TR-063, 2001, unpublished raw data.
  17. El-Sharkawy H, et al., “Platelet-Rich Plasma: Growth Factors and Pro- and Anti-Inflammatory Properties.” J Periodontol 2007; 78(4): 661–669.
  18. Fiore S and CN Serhan, “Lipoxin A4 Receptor Activation is Distinct from that of the Formyl Peptide Receptor in Myeloid Cells: Inhibition of CD11/18 Expression by Lipoxin A4-Lipoxin A4 Receptor Interaction.” Biochemistry 1995; 34(51): 16678–16686.
  19. Alexander RW, “Use of Microcannula Closed Syringe System for Safe and Effective Lipoaspiration and Small Volume Autologous Fat Grafting.” Am J Cosmet Surg 2013; 30(2): 94–104.
  20. Alexander RW and B Harrell, “Autologous Fat Grafting: Use of Closed Syringe Microcannula System for Enhanced Autologous Structural Grafting.” Clin Cosmet Investig Dermatol 2013; 6: 91–102.
  21. Alexander R, “Understanding Adipose-Derived Stromal Vascular Fraction (AD-SVF) Cell Biology and Use on the Basis of Cellular, Chemical, Structural, and Paracrine Components: A Concise Review.” J Prolother 2012; 4: 855–869.
  22. Yamaguchi M, et al., “Revascularization Determines Volume Retention and Gene Expression by Fat Grafts in Mice.” Exp Biol Med 2005; 230(10): 742–748.
  23. Ansorge H, et al., “Autologous Fat Processing via the Revolve System: Quality and Quantity of Fat Retention Evaluated in an Animal Model.” Aesthet Surg J 2014; 34(3): 438–447.
  24. Hoareau L, et al., “Effect of Centrifugation and Washing on Adipose Graft Viability: A New Method to Improve Graft Efficiency.” J of Plast Reconstr Aesthet Surg 2013; 66(5): 712–719.
  25. Pak J, “Regeneration of Human Bones in Hip Osteonecrosis and Human Cartilage in Knee Osteoarthritis with Autologous Adipose-Tissue-Derived Stem Cells: A Case Series.” J Med Case Rep 2011; 5: 296.
  26. Shahrabi-Farahani S, et al., “Granulomatous Foreign Body Reaction to Dermal Cosmetic Fillers with Intraoral Migration.” Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117(1): 105–110.
  27. Sadati KS, et al., “Platelet-Rich Plasma (APC) Utilized To Promote Greater Graft Volume Retention in Autologous Fat Grafting.” The American Journal of Cosmetic Surgery 2006; 23(4): 203–211.
  28. Lee SC, et al., “Inflammatory Granuloma Caused by Injectable Soft Tissue Filler (Artecoll).” J Korean Assoc Oral Maxillofac Surg 2013: 39(4): 193–196.
  29. Zimmermann US and TJ Clerici, “The Histological Aspects of Fillers Complications.” Semin Cutan Med Surg 2004; 23(4): 241–250.
  30. Tang YQ, et al., “Antimicrobial Peptides from Human Platelets.” Infect Immun 2002; 70(12): 6524–6533.
  31. Marx RE, “Platelet-Rich Plasma (APC): What is APC and What is Not APC?” Implant Dent 2001; 10(4): 225–228.
  32. Eppley BL, et al., “Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing.” Plast Reconstr Surg 2004; 114(6): 1502–1508.
  33. Drago L, et al., “Antimicrobial Activity of Pure Platelet-Rich Plasma Against Microorganisms Isolated from Oral Cavity.” BMC Microbiology 2013: 13(47): 1–5.
  34. Tidwell L, et al., “Harvest Technologies BMAC Data Summary.” 2014, unpublished raw data.
  35. Körbling M, et al., “Adult Stem Cells and Tissue Repair.” Bone Marrow Transplant 2003; 32: S23–S24.
  36. Bourin P, et al., “Stromal Cells from the Adipose Tissue-Derived Stromal Vascular Fraction and Culture Expanded Adipose Tissue-Derived Stromal/Stem Cells: A Joint Statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).” Cytotherapy 2013; 15(6): 641–648.
  37. Kevy S and MS Jacobson, “Comparative Analysis of Bone Marrow Concentrates Prepared by the Harvest Terumo SmartPrep System and the Cytomedix Angel System.” 2014, unpublished raw data.
  38. Immune Disease Institute 2009 Platelet Rich Plasma Preparation: A Comparison of the Harvest SmartPReP® 2 APC+® with the Arthrex ACP
  39. Gazdag AR, et al., “Alternatives to Autogenous Bone Graft: Efficacy and Indications.” J Am Acadf Orthop Surg 1995; 3(1): 1–8.
  40. Hernigou P, et al., “The Use of Percutaneous Autologous Bone Marrow Transplantation in Nonunion and Avascular Necrosis of Bone.” J Bone Joint Surg Br 2005; 87(7): 896–902.
  41. Hendrich C, et al., “Safety of Autologous Bone Marrow Aspiration Concentrate Transplantation: Initial Experiences in 101 Patients.” Orthop Rev 2009; 1(2): 99–103.
  42. Gosens T, “Ongoing Positive Effect of Platelet-Rich Plasma versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial with 2-Year Follow Up.” Am J Sports Med 2011; 39(6): 1200–1208.
  43. Monto RR, “Platelet-Rich Plasma Efficacy versus Corticosteroid Injection Treatment for Chronic Severe Plantar Fasciitis.” Foot Ankle Int 2014; 35(4): 313–318.
  44. Kon, et al. 2011 “Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis.” Arthoscopy 2011; 27(11): 1490-501.
  45. Gimble, et al. 2013 “Adipose tissue as a stem cell source for musculo-skeletal regeneration.” Front Biosci (Schol Ed); 3: 69-81.
  46. Kim Y and Jeong J, 2014 “Clinical Application of Adipose Stem Cells in Plastic Surgery.” The Korean Academy of Medical Sciences. 2014; 29: 462-467.
  47. Kevy SV and MS Jacobson, “Comparison of Bone Marrow Concentrates Prepared by the Harvest/Terumo BMAC® System and the Thermogenesis Res-Q™ 60 System.” 2012, unpublished raw data.
  48. Hegde V, et al., “A Prospective Comparison of Three Approved Systems for Autologous Bone Marrow Concentration Demonstrated Nonequivalency in Progenitor Cell Number and Concentration.” Journal of Orthopaedic Trauma 2014; 28(10): 591–598.
  49. Kevy SV and MS Jacobson, “Comparative Analysis of Bone Marrow Concentrate and Platelet Rich Plasma Prepared by the Harvest® Terumo SmartPRep System and the EmCyte Elite System.” 2014, unpublished raw data.
  50. Harvest/Terumo BCT, “The Composition of APC Produced from 5 Major APC Devices: A Comparison Study.” 2013 presentation, SL161, unpublished raw data.
  51. Kochan A, et al., “Platelet-Rich Plasma Preparation: A Comparison of the Harvest SmartPReP® 2 APC+ with the Arteriocyte Magellan®.” 2009, unpublished raw data.
  52. Hackel J, et al., “Platelet Concentrate Preparation: A Comparison of the Harvest SmartPReP® APC® with the Emcyte Genesis™.” 2010, unpublished raw data.
  53. Middleton KK, et al., “Evaluation of the Effects of Autologous Platelet Concentrate (APC) Therapy Involved in the Healing of Sports-Related Soft Tissue Injuries.” The Iowa Orthopaedic Journal 2012; 32: 150–163.
  54. Kevy, S., et al., “Defining the Composition and Healing Effect of Platelet-Rich Plasma for Regenerative Medicine.” Poster Session; 2010, presented at: TERMIS-Americas.
  55. Chen G, et al., “TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation.” International Journal of Biological Sciences 2012; 8 (2): 272–288.
  56. Caplan A. “Why Are MSCs Therapeutic? New Data: New Insight.” J Pathol 2009; 217 (2): 318–324.
  57. Korbling M, et al. “Adult stem cells and tissue repair.” Bone Marrow Transplantation 2003; 32, S23-S24.